Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age

P N Filimonov; T G Sukhenko; N I Gavrilova; V A Shkurupii

doi:10.1007/s10517-005-0284-4

Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age

Bull Exp Biol Med. 2005 Mar;139(3):324-7. doi: 10.1007/s10517-005-0284-4.

[Article in English, Russian]

Authors

P N Filimonov¹, T G Sukhenko, N I Gavrilova, V A Shkurupii

Affiliation

¹ Novosibirsk State Medical Academy, and Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

PMID: 16027843
DOI: 10.1007/s10517-005-0284-4

Abstract

In young, adult, and old mice fibrosis was induced by administration of CC1(4) and treated with IFN-alpha; liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.

Publication types

Comparative Study

MeSH terms

Aging / drug effects*
Aging / immunology*
Animals
Carbon Tetrachloride
Cells, Cultured
Interferon-alpha / pharmacology
Interferon-alpha / therapeutic use*
Liver Cirrhosis, Experimental / chemically induced
Liver Cirrhosis, Experimental / drug therapy*
Liver Cirrhosis, Experimental / pathology
Male
Mice
Mice, Inbred C57BL

Substances

Interferon-alpha
Carbon Tetrachloride