Abstract
Earlier work seems to suggest that overexpression of uncoupling protein 1 would be anti-inflammatory. However, new findings show that expression of uncoupling protein 1 in aortic smooth muscle cells of mice increases reactive oxygen species, activates the renin-angiotensin system, elevates blood pressure, and worsens atherosclerosis.
MeSH terms
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Angiotensins / metabolism
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Animals
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Arteriosclerosis / metabolism
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Blood Pressure
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Humans
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Inflammation / metabolism
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Inflammation / pathology
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Ion Channels
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mitochondrial Proteins
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Muscle, Smooth, Vascular / metabolism*
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Muscle, Smooth, Vascular / pathology
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Phospholipids / metabolism
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Reactive Oxygen Species / metabolism
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Renin / metabolism
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Uncoupling Protein 1
Substances
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Angiotensins
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Carrier Proteins
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Ion Channels
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Membrane Proteins
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Mitochondrial Proteins
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Phospholipids
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Reactive Oxygen Species
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UCP1 protein, human
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Ucp1 protein, mouse
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Uncoupling Protein 1
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Renin