Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2)

Jun-Hyeog Jang

doi:10.1007/s10529-005-5624-y

Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2)

Biotechnol Lett. 2005 Jun;27(11):749-52. doi: 10.1007/s10529-005-5624-y.

Author

Jun-Hyeog Jang¹

Affiliation

¹ Department of Biochemistry, Inha University College of Medicine, Incheon 400-712, Korea. juhjang@inha.ac.kr

PMID: 16086254
DOI: 10.1007/s10529-005-5624-y

Abstract

Keratinocyte growth factor-2 (KGF-2) is found in dermal papilla fibroblasts and its receptor, fibroblast growth factor receptor 2 (FGFR2), in the neighboring outer root sheath of keratinocytes. Administration of recombinant human KGF-2 (rhKGF-2) at 10 ng ml(-1) significantly stimulated human hair-follicle cell proliferation in organ culture (26-35%). Thus, rhKGF-2 is a promising therapeutic agent to stimulate human hair growth.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation / drug effects*
Dose-Response Relationship, Drug
Escherichia coli / genetics
Fibroblast Growth Factor 10 / genetics
Fibroblast Growth Factor 10 / pharmacology*
Hair Follicle / cytology
Hair Follicle / drug effects*
Humans
Recombinant Proteins / biosynthesis
Recombinant Proteins / isolation & purification
Recombinant Proteins / pharmacology

Substances

FGF10 protein, human
Fibroblast Growth Factor 10
Recombinant Proteins