Abstract
The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / metabolism*
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Alzheimer Disease / therapy
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism*
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Amyloid beta-Peptides / toxicity
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Amyloid beta-Peptides / ultrastructure
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Amyloid beta-Protein Precursor / chemistry
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Amyloid beta-Protein Precursor / metabolism
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Humans
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Protein Structure, Quaternary
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor