Abstract
A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt-Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.
MeSH terms
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Adolescent
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Adult
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Aged
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Asian People / genetics
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Black People / genetics
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Brazil
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Codon / genetics*
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Creutzfeldt-Jakob Syndrome / epidemiology
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Creutzfeldt-Jakob Syndrome / ethnology
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Creutzfeldt-Jakob Syndrome / genetics*
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Gene Frequency / genetics*
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Genetic Predisposition to Disease / epidemiology
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Genotype*
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Humans
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Indians, South American / genetics
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Middle Aged
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Peptide Fragments / genetics*
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Prions / genetics*
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Quantitative Trait, Heritable
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White People / genetics
Substances
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Codon
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Peptide Fragments
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Prions
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prion protein (127-147)