Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations

Eur J Epidemiol. 2005;20(7):593-5. doi: 10.1007/s10654-005-7455-5.

Abstract

A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt-Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asian People / genetics
  • Black People / genetics
  • Brazil
  • Codon / genetics*
  • Creutzfeldt-Jakob Syndrome / epidemiology
  • Creutzfeldt-Jakob Syndrome / ethnology
  • Creutzfeldt-Jakob Syndrome / genetics*
  • Gene Frequency / genetics*
  • Genetic Predisposition to Disease / epidemiology
  • Genotype*
  • Humans
  • Indians, South American / genetics
  • Middle Aged
  • Peptide Fragments / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Prions / genetics*
  • Quantitative Trait, Heritable
  • White People / genetics

Substances

  • Codon
  • Peptide Fragments
  • Prions
  • prion protein (127-147)