Abstract
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Amino Acid Sequence
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Animals
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Blood Proteins / genetics
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Blood Proteins / metabolism*
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Cell Line
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Cell Membrane / chemistry
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Cell Membrane / metabolism
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism*
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism*
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Molecular Sequence Data
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Multigene Family
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Phospholipids / metabolism
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Phosphoproteins / genetics
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Phosphoproteins / metabolism*
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Protein Binding
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Protein Structure, Tertiary
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Rats
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Sequence Alignment
Substances
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Adaptor Proteins, Signal Transducing
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Blood Proteins
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Cytoskeletal Proteins
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FRMD6 protein, human
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Membrane Proteins
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Microfilament Proteins
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Phospholipids
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Phosphoproteins
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Recombinant Fusion Proteins
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ezrin
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moesin
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radixin