Abstract
Transglutaminase 2 (TG2) belongs to a family of calcium-dependent enzymes that catalyze transamidation reaction, producing polymerized, polyaminated or deamidated proteins. Recently, a growing number of viral proteins as well as cellular proteins with which they interact have been found to be modified by TG2, suggesting a novel function for TG2 in viral pathogenesis. This review summarizes the results of relevant research, examines the mechanisms underlying TG2 function in host-virus interactions and proposes a model for viral pathogenesis involving TG2.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / chemistry
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Cross-Linking Reagents / pharmacology
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GTP-Binding Proteins / metabolism
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GTP-Binding Proteins / physiology*
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Humans
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Oxidative Stress
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Protein Binding
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Protein Conformation
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Protein Glutamine gamma Glutamyltransferase 2
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Protein Processing, Post-Translational
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Transglutaminases / metabolism
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Transglutaminases / physiology*
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Virus Diseases / enzymology*
Substances
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Cross-Linking Reagents
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases
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GTP-Binding Proteins
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Calcium