Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J E Tissing; Melchior Lauten; Jules P P Meijerink; Monique L den Boer; Jan Willem Koper; Peter Sonneveld; Rob Pieters

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Haematologica. 2005 Sep;90(9):1279-81.

Authors

Wim J E Tissing, Melchior Lauten, Jules P P Meijerink, Monique L den Boer, Jan Willem Koper, Peter Sonneveld, Rob Pieters

PMID: 16154856

Abstract

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

Publication types

Comparative Study
Letter

MeSH terms

Child
Cohort Studies
Drug Resistance, Neoplasm / genetics
Gene Expression Regulation / drug effects
Gene Expression Regulation / physiology
Glucocorticoids / biosynthesis
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Prednisolone / therapeutic use*
Protein Isoforms / biosynthesis
Receptors, Glucocorticoid / biosynthesis*
Receptors, Glucocorticoid / genetics

Substances

Glucocorticoids
Protein Isoforms
Receptors, Glucocorticoid
Prednisolone