Abstract
We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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DNA Transposable Elements / genetics*
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Female
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Male
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Middle Aged
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins / genetics*
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Promoter Regions, Genetic / genetics*
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Proto-Oncogene Proteins c-bcl-2 / genetics*
Substances
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DNA Transposable Elements
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins
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Proto-Oncogene Proteins c-bcl-2