Abstract
Immune complex nephritis induced by bovine serum albumin (BSA) and horseradish peroxidase (HRP) was superimposed upon spontaneous hypertensive rats (SHR rats) which were pretreated with polyvinyl alcohol (PVA). PVA accumulated predominantly in the mesangium, and the superimposed nephritis developed more accelerated glomerular damage with marked capillary deposition of immune complexes than control animals which were not pretreated with PVA.
MeSH terms
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Animals
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Complement C3 / analysis
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Fluorescent Antibody Technique
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Horseradish Peroxidase
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Hypertension / complications*
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Immune Complex Diseases / etiology*
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Immune Complex Diseases / immunology
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Immunoglobulin G / analysis
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Kidney Medulla / immunology*
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Nephritis / etiology*
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Nephritis / immunology
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Polyvinyl Alcohol / pharmacology
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Rats
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Serum Albumin, Bovine
Substances
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Complement C3
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Immunoglobulin G
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Serum Albumin, Bovine
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Polyvinyl Alcohol
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Horseradish Peroxidase