Abstract
Synovial sarcoma (SS) arises in soft tissues but may invade adjacent bone. We describe a case of SS presenting as aggressive lysis of the proximal ulna, the imaging of which suggested a primary bone lesion. Needle biopsy showed a "small round blue cell tumour", and a primitive neuroectodermal tumour (PNET)/Ewing sarcoma was suggested on the basis of the imaging appearances. The definitive diagnosis of synovial sarcoma was made following molecular genetic studies, which demonstrated a fusion product incorporating the genes SYT and SSX1. The importance of correct diagnosis to guide appropriate management, and, therefore, the necessity for molecular genetic studies, is discussed.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bone Neoplasms / diagnosis*
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Bone Neoplasms / diagnostic imaging
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Bone Neoplasms / genetics
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Diagnosis, Differential
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Elbow Joint / diagnostic imaging
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Elbow Joint / pathology
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Humans
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Male
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Neoplasm Proteins / genetics
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Neuroectodermal Tumors, Primitive / diagnosis*
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Neuroectodermal Tumors, Primitive / diagnostic imaging
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Neuroectodermal Tumors, Primitive / genetics
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Proto-Oncogene Proteins / genetics
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Radiography
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Repressor Proteins / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Sarcoma, Synovial / diagnosis*
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Sarcoma, Synovial / diagnostic imaging
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Sarcoma, Synovial / genetics
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Ulna* / diagnostic imaging
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Ulna* / pathology
Substances
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Repressor Proteins
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SS18 protein, human
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synovial sarcoma X breakpoint proteins