Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis

Bull Exp Biol Med. 2005 Jun;139(6):662-4. doi: 10.1007/s10517-005-0371-6.

Abstract

A case--control study was conducted to evaluate the relationship between C481T and G590A polymorphisms of arylamine-N-acetyltransferase 2 and predisposition to atopic dermatitis in children. Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Alleles
  • Amino Acid Substitution
  • Arylamine N-Acetyltransferase / genetics*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • DNA / blood
  • DNA / genetics
  • Dermatitis, Atopic / diagnosis
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Glycine / metabolism
  • Heterozygote
  • Humans
  • Incidence
  • Infant
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors
  • Sex Factors

Substances

  • DNA
  • Arylamine N-Acetyltransferase
  • NAT2 protein, human
  • Glycine