Abstract
The onset of type 1 diabetes mellitus (T1DM) is directly linked to the expression of class II MHC molecules. The NOD mouse, which is an excellent animal model for the human disease, expresses the I-Ag7 molecule that shares many features with the human diabetogenic class II MHC alleles. In this review, the structural, biochemical, and biological properties of the I-Ag7 molecules and how they relate to onset of diabetes is discussed. In particular, the focus is on the unique properties of peptide selection by I-Ag7 that reveal the preferred binding motif of diabetogenic MHC molecules and its role in display of peptides derived from islet beta cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen Presentation
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Binding Sites
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Diabetes Mellitus, Type 1 / immunology*
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Diabetes Mellitus, Type 1 / metabolism*
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Diabetes Mellitus, Type 1 / pathology
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Disease Models, Animal
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Disease Susceptibility
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HLA-DQ Antigens / chemistry
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HLA-DQ Antigens / genetics
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HLA-DQ Antigens / immunology
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HLA-DQ Antigens / metabolism*
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Histocompatibility Antigens Class II / chemistry
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Histocompatibility Antigens Class II / genetics
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Antigens Class II / metabolism*
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Humans
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Islets of Langerhans / immunology
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Islets of Langerhans / metabolism*
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Islets of Langerhans / pathology
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Mice
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Mice, Inbred NOD
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Peptide Fragments
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Protein Binding / immunology
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Protein Interaction Domains and Motifs / immunology
Substances
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HLA-DQ Antigens
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HLA-DQ8 antigen
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Histocompatibility Antigens Class II
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I-A g7 antigen
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Peptide Fragments