Abstract
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Animals, Genetically Modified
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Cell Lineage
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Cytokines / metabolism
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Epithelial Cells / cytology
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Epithelial Cells / physiology
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Epithelial Cells / transplantation
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Female
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Gene Expression Regulation*
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Humans
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Mammary Glands, Animal / anatomy & histology
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Mammary Glands, Animal / growth & development*
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Mammary Glands, Animal / physiology*
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Mammary Glands, Human / anatomy & histology
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Mammary Glands, Human / growth & development*
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Mammary Glands, Human / physiology*
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Pregnancy
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Signal Transduction / physiology
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Transcription Factors / metabolism
Substances
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Cytokines
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Transcription Factors