From transcription to mRNA: PAF provides a new path

Emanuel Rosonina; James L Manley

doi:10.1016/j.molcel.2005.10.004

From transcription to mRNA: PAF provides a new path

Mol Cell. 2005 Oct 28;20(2):167-8. doi: 10.1016/j.molcel.2005.10.004.

Authors

Emanuel Rosonina¹, James L Manley

Affiliation

¹ Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

PMID: 16246718
DOI: 10.1016/j.molcel.2005.10.004

Abstract

Two new studies reveal a novel connection between transcription and pre-mRNA processing: the Paf1 elongation complex is involved in the 3' end formation of polyadenylated and nonpolyadenylated RNA polymerase II transcripts.

Publication types

Review
Comment

MeSH terms

Gene Expression Regulation
Humans
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
RNA 3' End Processing / physiology*
RNA Polymerase II / metabolism*
RNA Processing, Post-Transcriptional / physiology*
RNA, Messenger / genetics
RNA, Messenger / metabolism*
Saccharomyces cerevisiae / enzymology
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / genetics
Saccharomyces cerevisiae Proteins / metabolism*
Transcription Factors
Transcription, Genetic

Substances

Nuclear Proteins
PAF1 protein, S cerevisiae
PAF1 protein, human
RNA, Messenger
Saccharomyces cerevisiae Proteins
Transcription Factors
RNA Polymerase II