A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Clin Infect Dis. 2005 Dec 15;41(12):1817-9. doi: 10.1086/498156. Epub 2005 Nov 8.

Abstract

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fever / epidemiology
  • Fever / genetics*
  • Humans
  • Incidence
  • Infant
  • Infections / epidemiology
  • Infections / genetics*
  • Intercellular Adhesion Molecule-1 / genetics*
  • Kenya / epidemiology
  • Malaria / epidemiology
  • Malaria / genetics
  • Polymorphism, Genetic*

Substances

  • Intercellular Adhesion Molecule-1