Marginal zone lymphoma of the lacrimal gland spreading to the lung and the bone marrow 11 years after first symptoms

Annette Zimpfer; Martin C Freund; Stephan Dirnhofer; Eberhard Gunsilius; Berthold Streubel; Andreas Chott; Alexandar Tzankov

doi:10.1007/s00428-005-0108-y

Marginal zone lymphoma of the lacrimal gland spreading to the lung and the bone marrow 11 years after first symptoms

Virchows Arch. 2006 Mar;448(3):361-5. doi: 10.1007/s00428-005-0108-y. Epub 2005 Nov 17.

Authors

Annette Zimpfer¹, Martin C Freund, Stephan Dirnhofer, Eberhard Gunsilius, Berthold Streubel, Andreas Chott, Alexandar Tzankov

Affiliation

¹ Institute of Pathology, University of Basel, Basel, Switzerland.

PMID: 16328352
DOI: 10.1007/s00428-005-0108-y

Abstract

We report on the case of a 52-year-old male presenting with an extranodal marginal zone lymphoma of the mucosa-associated tissue (MALT lymphoma) in the lung 11 years after radiotherapy for a MALT lymphoma of the lacrimal gland, which was primarily diagnosed as dacryoadenitis. Both tumors were investigated by immunohistochemistry and molecular techniques demonstrating their clonal genetic relationship. Both harbored the t(14;18)(q32;q21) and a trisomy 3 and showed identical immunoglobulin heavy-chain gene rearrangements. At the time of pulmonary relapse, clonal CD20- and CD43-positive bone marrow B lymphocytes were detected as well. The elaboration of this case emphasizes the importance of the combined use of modern diagnostic methods for establishment of correct diagnosis of MALT lymphomas at late relapses, which is essential for proper patient management.

Publication types

Case Reports

MeSH terms

Adult
Biomarkers, Tumor / metabolism
Bone Marrow Neoplasms / genetics
Bone Marrow Neoplasms / metabolism
Bone Marrow Neoplasms / secondary*
Bone Marrow Neoplasms / therapy
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 3
Combined Modality Therapy
DNA, Neoplasm / analysis
Dacryocystitis / diagnosis
Diagnosis, Differential
Eye Neoplasms / genetics
Eye Neoplasms / metabolism
Eye Neoplasms / pathology*
Eye Neoplasms / therapy
Humans
In Situ Hybridization, Fluorescence
Lacrimal Apparatus / metabolism
Lacrimal Apparatus / pathology*
Lung Neoplasms / genetics
Lung Neoplasms / metabolism
Lung Neoplasms / secondary*
Lung Neoplasms / therapy
Lymphoma, B-Cell, Marginal Zone / genetics
Lymphoma, B-Cell, Marginal Zone / metabolism
Lymphoma, B-Cell, Marginal Zone / pathology*
Lymphoma, B-Cell, Marginal Zone / therapy
Male
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary / genetics
Neoplasms, Multiple Primary / metabolism
Neoplasms, Multiple Primary / pathology*
Radiography, Thoracic
Translocation, Genetic
Trisomy

Substances

Biomarkers, Tumor
DNA, Neoplasm