Abstract
Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Chondroitin Sulfate Proteoglycans / biosynthesis*
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Disease Progression
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Enzymologic*
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Neoplasm Invasiveness
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Protein Tyrosine Phosphatases / biosynthesis*
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Receptor-Like Protein Tyrosine Phosphatases, Class 4
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Receptor-Like Protein Tyrosine Phosphatases, Class 5
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Receptors, Cell Surface / biosynthesis*
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Stomach Neoplasms / enzymology*
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Stomach Neoplasms / pathology
Substances
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Chondroitin Sulfate Proteoglycans
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Receptors, Cell Surface
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PTPRA protein, human
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PTPRZ1 protein, human
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Protein Tyrosine Phosphatases
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Receptor-Like Protein Tyrosine Phosphatases, Class 4
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Receptor-Like Protein Tyrosine Phosphatases, Class 5