PIDD: a switch hitter

Zhao-Hui Wu; Angela Mabb; Shigeki Miyamoto

doi:10.1016/j.cell.2005.11.025

PIDD: a switch hitter

Cell. 2005 Dec 16;123(6):980-2. doi: 10.1016/j.cell.2005.11.025.

Authors

Zhao-Hui Wu¹, Angela Mabb, Shigeki Miyamoto

Affiliation

¹ Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.

PMID: 16360026
DOI: 10.1016/j.cell.2005.11.025

Abstract

In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.

Publication types

Comment

MeSH terms

Apoptosis / physiology*
Carrier Proteins / physiology*
Cell Nucleus / metabolism
Cytoplasm / metabolism
DNA Damage / physiology*
Death Domain Receptor Signaling Adaptor Proteins
Humans
I-kappa B Kinase / metabolism
Models, Biological
NF-kappa B / metabolism
SUMO-1 Protein / metabolism
Signal Transduction

Substances

Carrier Proteins
Death Domain Receptor Signaling Adaptor Proteins
IKBKG protein, human
NF-kappa B
PIDD1 protein, human
SUMO-1 Protein
I-kappa B Kinase