Abstract
Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anaplastic Lymphoma Kinase
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Diagnosis, Differential
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Female
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Granuloma, Plasma Cell / diagnosis*
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Granuloma, Plasma Cell / enzymology
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Granuloma, Plasma Cell / genetics
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Humans
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Ileal Diseases / diagnosis*
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Ileal Diseases / enzymology
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Ileal Diseases / pathology
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Ileocecal Valve / pathology*
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Ileocecal Valve / surgery
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In Situ Hybridization, Fluorescence
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Intussusception / diagnosis*
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Intussusception / enzymology
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Intussusception / surgery
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism*
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Receptor Protein-Tyrosine Kinases
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Tomography, X-Ray Computed
Substances
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Recombinant Fusion Proteins
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ALK protein, human
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Anaplastic Lymphoma Kinase
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases