[The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients]

Tsitol Genet. 2005 Nov-Dec;39(6):50-4.
[Article in Russian]

Abstract

Large multifunctional protease LMP2 (Arg60-->His) and LMP7 (Lys145-->Gln) gene allelic polymorphism in 200 patients with acute coronary syndrome and in 80 practically healthy people was determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P > 0.05 by chi2-test). Analysis of LMP7 gene polymorphism has shown that Lys/Lys - 89.5 %, Lys/Gln - 10.5 %, Gin/Gin - 0 % (in control group 93.8, 6.2, 0 % correspondingly; P > 0.05). The data show that LMP2 and LMP7 gene polymorphism is not a risk factor of acute coronary syndrome in Ukrainian population.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles*
  • Case-Control Studies
  • Catalytic Domain
  • Chi-Square Distribution
  • Coronary Disease / enzymology
  • Coronary Disease / genetics*
  • Female
  • Gene Frequency*
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Endopeptidase Complex / genetics*

Substances

  • Proteasome Endopeptidase Complex