Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region

J Proteome Res. 2006 Jan;5(1):44-53. doi: 10.1021/pr050235f.

Abstract

Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.

MeSH terms

  • Animals
  • Chromosomes, Human, Pair 21 / genetics*
  • Down Syndrome / genetics
  • Down Syndrome / metabolism*
  • Gene Expression Regulation
  • Hippocampus / chemistry
  • Hippocampus / metabolism*
  • Humans
  • Mice
  • Mice, Transgenic
  • Protein Biosynthesis / genetics
  • Proteins / analysis
  • Proteins / genetics
  • Proteins / metabolism
  • Proteome / analysis
  • Proteome / genetics
  • Proteome / metabolism*
  • Proteomics
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism

Substances

  • Proteins
  • Proteome
  • RNA, Messenger