Purpose: The purpose of this study was to investigate the relationship between TNFalpha-308 gene polymorphisms and susceptibility to chronic periodontitis in Chinese patients.
Methods: DNA samples with buccal swabs were collected from 63 severe CP patients, 103 initial to moderate CP patients, and 80 healthy controls in Chinese Han nationality. The TNFA-308 gene polymorphisms were analyzed with PCR-RFLP. The data were analyzed by X(2) test using SPSS10.0.
Results: There were no significant genotype distribution differences of TNFA-308 between either two of the three subject groups.
Conclusion: Further study was needed since we did not find the relationship between TNFA-308 gene polymorphism and periodontitis in this present study.