Global distribution of a novel trinucleotide microsatellite polymorphism (ATA)n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis

Int J Immunogenet. 2006 Feb;33(1):11-5. doi: 10.1111/j.1744-313X.2006.00547.x.

Abstract

We identified a novel trinucleotide (ATA)n repeat polymorphism in intron 8 of SLC11AI, a candidate gene for susceptibility to tuberculosis (TB) infection. We characterized the frequency of this polymorphism in 485 individuals originating from eight globally diverse human populations and compared the distribution of (ATA)n alleles in 146 adults and in 80 cord blood samples from newborns in the Gambian population. Lastly, we tested for association of this microsatellite with pulmonary TB in 318 TB cases and 146 controls in the Gambian population. We found no significant difference in frequency or distribution of alleles in adult and cord blood samples, and we found no significant association between this marker and pulmonary TB.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Case-Control Studies
  • Cation Transport Proteins / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Polymorphism, Genetic
  • Trinucleotide Repeats*
  • Tuberculosis, Pulmonary / genetics*

Substances

  • Cation Transport Proteins
  • natural resistance-associated macrophage protein 1