Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups

D A Akkad; P Jagiello; P Szyld; R Goedde; S Wieczorek; W L Gross; J T Epplen

doi:10.1111/j.1744-313X.2006.00568.x

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups

Int J Immunogenet. 2006 Feb;33(1):59-61. doi: 10.1111/j.1744-313X.2006.00568.x.

Authors

D A Akkad¹, P Jagiello, P Szyld, R Goedde, S Wieczorek, W L Gross, J T Epplen

Affiliation

¹ Department of Human Genetics, Ruhr-University, 44801 Bochum, Germany.

PMID: 16426246
DOI: 10.1111/j.1744-313X.2006.00568.x

Abstract

We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis. The recently reported association in a northern population of the MHC2TA variation with these autoimmune diseases is not evident in the German population.

MeSH terms

Arthritis, Juvenile / genetics
Arthritis, Rheumatoid / genetics
Autoimmune Diseases / genetics*
Cohort Studies
Gene Frequency
Genetic Predisposition to Disease*
Germany
Granulomatosis with Polyangiitis / genetics
Humans
Multiple Sclerosis / genetics
Narcolepsy / genetics
Nuclear Proteins / genetics*
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Trans-Activators / genetics*

Substances

MHC class II transactivator protein
Nuclear Proteins
Trans-Activators