Transcriptional repression of interleukin-2 in human systemic lupus erythematosus

Christina G Katsiari; George C Tsokos

doi:10.1016/j.autrev.2005.08.009

Transcriptional repression of interleukin-2 in human systemic lupus erythematosus

Autoimmun Rev. 2006 Feb;5(2):118-21. doi: 10.1016/j.autrev.2005.08.009. Epub 2005 Sep 26.

Authors

Christina G Katsiari¹, George C Tsokos

Affiliation

¹ Dept. of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20190, USA. christina.katsiari@na.amedd.army.mil

PMID: 16431340
DOI: 10.1016/j.autrev.2005.08.009

Abstract

T cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response. We discuss herein the abnormalities underlying IL-2 deficiency in SLE T cells.

Publication types

Review

MeSH terms

Binding Sites / genetics
Cyclic AMP Response Element Modulator / metabolism
Gene Expression Regulation / genetics*
Humans
Interleukin-2 / genetics*
Interleukin-2 / metabolism
Lupus Erythematosus, Systemic / genetics
Lupus Erythematosus, Systemic / metabolism*
Models, Biological
Promoter Regions, Genetic / genetics
Transcription Factor AP-1 / metabolism
Transcription Factor RelA / metabolism
Transcription, Genetic / genetics

Substances

CREM protein, human
Interleukin-2
Transcription Factor AP-1
Transcription Factor RelA
Cyclic AMP Response Element Modulator