Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients

Mol Genet Metab. 2006 Jun;88(2):196-8. doi: 10.1016/j.ymgme.2005.12.006. Epub 2006 Feb 2.

Abstract

Objectives: It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis.

Methods: Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis.

Results: Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis.

Conclusion: The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Carrier Proteins / genetics*
  • Fatty Liver / etiology
  • Fatty Liver / genetics*
  • Fatty Liver / metabolism
  • Female
  • Hepatitis C, Chronic / complications*
  • Hepatitis C, Chronic / metabolism
  • Humans
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Viral Core Proteins / metabolism

Substances

  • Carrier Proteins
  • Viral Core Proteins
  • microsomal triglyceride transfer protein