RETRACTED: Selective targeting of checkpoint kinase 1 in tumor cells with a novel potent oncolytic adenovirus

Qinglei Gao; Jianfeng Zhou; Xiaoyuan Huang; Gang Chen; Fei Ye; Yunping Lu; Kanyan Li; Liang Zhuang; Mei Huang; Gang Xu; Shxuan Wang; Ding Ma

doi:10.1016/j.ymthe.2005.12.009

RETRACTED: Selective targeting of checkpoint kinase 1 in tumor cells with a novel potent oncolytic adenovirus

Mol Ther. 2006 May;13(5):928-937. doi: 10.1016/j.ymthe.2005.12.009. Epub 2006 Feb 3.

Authors

Qinglei Gao¹, Jianfeng Zhou¹, Xiaoyuan Huang¹, Gang Chen¹, Fei Ye¹, Yunping Lu¹, Kanyan Li¹, Liang Zhuang¹, Mei Huang¹, Gang Xu¹, Shxuan Wang¹, Ding Ma²

Affiliations

¹ Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China.
² Cancer Biology Research Center, TongJi Hospital, TongJi Medical School, Huazhong University of Science & Technology, WuHan, Hubei 430030, People's Republic of China. Electronic address: dma@tjh.tjmu.edu.cn.

PMID: 16459149
DOI: 10.1016/j.ymthe.2005.12.009

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editor-in-chief. Similarities were reported between images in this article and an article in Clinical Cancer Research (Zhou et al., 2005, Clin. Cancer Res. 11, 8431-8440, https://10.1158/1078-0432.CCR-05-1085). Q.J., J.Z., X.H., G.C., Y.L., K.L., L.Z., and D.M. were all authors of the Clinical Cancer Research paper as well. These concerns were initially reported in a Pubpeer thread (https://pubpeer.com/publications/FF881782FF5AFD316D42E0C0F00766). Image analysis performed by the editorial office confirmed findings of image recycling in Figures 2A and 3B of the Molecular Therapy article. This reuse (and in part misrepresentation) of data without appropriate attribution represents a severe abuse of the scientific publishing system.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

Adenoviridae / genetics*
Adenoviridae / physiology
Adenovirus E1A Proteins / deficiency*
Adenovirus E1A Proteins / genetics
Animals
Antineoplastic Agents / therapeutic use
Carcinoma, Hepatocellular / enzymology
Carcinoma, Hepatocellular / therapy*
Carcinoma, Hepatocellular / virology
Cell Line
Cell Line, Tumor
Cell Survival
Checkpoint Kinase 1
Cisplatin / therapeutic use
Cytopathogenic Effect, Viral / physiology
DNA, Antisense / genetics
Female
Gene Targeting*
Genetic Vectors / administration & dosage
Genetic Vectors / therapeutic use
HeLa Cells
Humans
Liver Neoplasms / enzymology
Liver Neoplasms / therapy*
Liver Neoplasms / virology
Mice
Mice, Inbred BALB C
Mice, Nude
Models, Genetic
Promoter Regions, Genetic
Protein Kinases / genetics*
Protein Kinases / metabolism
Virus Replication
Xenograft Model Antitumor Assays

Substances

Adenovirus E1A Proteins
Antineoplastic Agents
DNA, Antisense
Protein Kinases
CHEK1 protein, human
Checkpoint Kinase 1
Chek1 protein, mouse
Cisplatin