Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

Infect Genet Evol. 2006 Sep;6(5):361-7. doi: 10.1016/j.meegid.2006.01.002. Epub 2006 Feb 7.

Abstract

Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3'UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P=0.02 and 0.03 respectively). INT4-D543N-3'UTR haplotypes showed an association with pulmonary TB (P=0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P=0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cation Transport Proteins / genetics*
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Peru / epidemiology
  • Polymorphism, Genetic*
  • Tuberculosis, Pulmonary / epidemiology
  • Tuberculosis, Pulmonary / genetics*

Substances

  • Cation Transport Proteins
  • natural resistance-associated macrophage protein 1