Abstract
Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Biomarkers, Tumor / blood*
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Cyclin-Dependent Kinase 4 / metabolism
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Fatal Outcome
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Gene Expression
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Humans
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Immunoenzyme Techniques
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Liposarcoma / blood*
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Liposarcoma / pathology
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Liposarcoma / surgery
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Male
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Neoplasm Recurrence, Local
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Proto-Oncogene Proteins c-mdm2 / metabolism
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RNA, Messenger / metabolism
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Retroperitoneal Neoplasms / metabolism
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Retroperitoneal Neoplasms / pathology*
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Reverse Transcriptase Polymerase Chain Reaction
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Soft Tissue Neoplasms / blood*
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Soft Tissue Neoplasms / pathology
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Soft Tissue Neoplasms / surgery
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alpha-Fetoproteins / genetics
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alpha-Fetoproteins / metabolism*
Substances
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Biomarkers, Tumor
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RNA, Messenger
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alpha-Fetoproteins
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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CDK4 protein, human
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Cyclin-Dependent Kinase 4