High expression of FMNL1 protein in T non-Hodgkin's lymphomas

Patricia M B Favaro; Fabiola Traina; Jose Vassallo; Pierre Brousset; George Delsol; Fernando F Costa; Sara T O Saad

doi:10.1016/j.leukres.2005.10.003

High expression of FMNL1 protein in T non-Hodgkin's lymphomas

Leuk Res. 2006 Jun;30(6):735-8. doi: 10.1016/j.leukres.2005.10.003. Epub 2006 Feb 21.

Authors

Patricia M B Favaro¹, Fabiola Traina, Jose Vassallo, Pierre Brousset, George Delsol, Fernando F Costa, Sara T O Saad

Affiliation

¹ Centro de Hematologia e Hemoterapia e Departamento de Clinica Medica, Universidade Estadual de Campinas, Brazil, and Department of Pathology and Inserm U563, Centre de Physiopathologie de Toulouse, Purpan Hospital, France.

PMID: 16494944
DOI: 10.1016/j.leukres.2005.10.003

Abstract

We recently cloned a novel Formin-family human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt. Here, we describe the expression of the FMNL1 protein in 54 frozen biopsies of non-Hodgkin's lymphoma (NHL) patients and five reactive lymph nodes. Western blot analysis revealed expression of FMNL1 in all samples studied, although the highest expression was in T-cell NHL (P<0.05).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Blotting, Western
Cytoskeletal Proteins / biosynthesis*
Cytoskeletal Proteins / genetics
Female
Formins
Gene Expression Regulation, Leukemic* / genetics
Humans
Lymph Nodes / metabolism
Lymph Nodes / pathology
Lymphoma, T-Cell / genetics
Lymphoma, T-Cell / metabolism*
Lymphoma, T-Cell / pathology
Male
Middle Aged
Neoplasm Proteins / biosynthesis*
Neoplasm Proteins / genetics

Substances

Cytoskeletal Proteins
FMNL1 protein, human
Formins
Neoplasm Proteins