The incidence of the JAK2 V617F mutation in patients with idiopathic erythrocytosis

Haematologica. 2006 Mar;91(3):413-4. Epub 2006 Feb 17.

Abstract

Sixty-three patients with erythrocytosis exhibiting a range of erythropoietin levels were screened for the JAK2 V617F mutation. One patient (1.6%) was found to have this mutation, and has remained stable for 9 years, suggesting that the JAK2 V617F mutation is rare in patients with idiopathic erythrocytosis.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Incidence
  • Janus Kinase 2
  • Middle Aged
  • Mutation*
  • Phenylalanine / genetics
  • Polycythemia / enzymology*
  • Polycythemia / epidemiology
  • Polycythemia / genetics*
  • Protein-Tyrosine Kinases / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Valine / genetics

Substances

  • Proto-Oncogene Proteins
  • Phenylalanine
  • Protein-Tyrosine Kinases
  • JAK2 protein, human
  • Janus Kinase 2
  • Valine