The results of several studies which have been published since 1992 evidence a significant correlation between DD genotype of angiotensin 1-converting enzyme (ACE) gene and development of coronary artery disease (CAD) in some populations. The authors of this article studied distribution of ACE gene I/D genotypes (II, ID, DD) in 102 patients with CAD and 50 controls without cardiovascular pathology or diabetes mellitus. The CAD diagnosis was confirmed by coronaroangiography. The study established a significant correlation between the presence of DD-ACE genotype and development of CAD. After exclusion of patients with classic risk factors (body mass index greater than 26 kg/m2; arterial hypertension; dislipidemia), this correlation remained. The results of the study demonstrate a significant positive correlation between the presence of DD genotype and high risk of CAD in this population, including people without such classic risk factors as obesity, arterial hypertension, or dislipidemia.