Abstract
Fms-like tyrosine kinase 1 (Flt-1), a receptor for vascular endothelial growth factor (VEGF), have two isoforms: membrane-bound form (mFlt-1) and soluble form. In the present study, we quantitatively evaluated expression level of mFlt-1 mRNA and VEGF mRNA in non-small cell lung cancer, and demonstrated the clinical significance of the ratio of mFlt-1 mRNA to VEGF mRNA (mFlt-1/VEGF). High mFlt-1/VEGF tumor showed a significantly lower microvessel density (P=0.004), and patients with high mFlt-1/VEGF tumor had a significantly favorable survival (P=0.037). Thus, the ratio of mFlt-1 mRNA to VEGF mRNA was inversely correlated with tumor angiogenesis, and was a significant prognostic factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antigens, CD / analysis
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Antigens, CD34 / analysis
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Carcinoma, Non-Small-Cell Lung / blood supply
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Carcinoma, Non-Small-Cell Lung / pathology*
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Carcinoma, Non-Small-Cell Lung / surgery
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Endoglin
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Immunohistochemistry
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Lung Neoplasms / blood supply
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Lung Neoplasms / pathology*
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Lung Neoplasms / surgery
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Male
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Membrane Proteins / genetics
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Middle Aged
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Multivariate Analysis
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Neovascularization, Pathologic / pathology*
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Prognosis
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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Receptors, Cell Surface / analysis
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Survival Analysis
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Vascular Endothelial Growth Factor A / genetics*
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Vascular Endothelial Growth Factor Receptor-1 / genetics*
Substances
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Antigens, CD
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Antigens, CD34
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ENG protein, human
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Endoglin
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Membrane Proteins
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RNA, Messenger
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Receptors, Cell Surface
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Vascular Endothelial Growth Factor A
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FLT1 protein, human
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Vascular Endothelial Growth Factor Receptor-1