Abstract
The accumulation of amyloid-beta peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-beta peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.
MeSH terms
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Alzheimer Disease / genetics
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Alzheimer Disease / metabolism*
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Amino Acid Sequence
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Amyloid Precursor Protein Secretases
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Amyloid beta-Peptides / genetics*
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Amyloid beta-Peptides / metabolism
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Amyloid beta-Protein Precursor / genetics*
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Animals
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Aspartic Acid Endopeptidases
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Endopeptidases / genetics*
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Humans
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LDL-Receptor Related Proteins
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Membrane Proteins / genetics
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Membrane Transport Proteins / genetics*
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Mice
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Mice, Knockout
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Molecular Sequence Data
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Presenilin-1
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Receptors, LDL / genetics*
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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LDL-Receptor Related Proteins
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Membrane Proteins
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Membrane Transport Proteins
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PSEN1 protein, human
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Presenilin-1
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Receptors, LDL
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SORL1 protein, human
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Amyloid Precursor Protein Secretases
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Endopeptidases
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Aspartic Acid Endopeptidases
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BACE1 protein, human
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Bace1 protein, mouse