sorLA: sorting out APP

Mol Interv. 2006 Apr;6(2):74-6, 58. doi: 10.1124/mi.6.2.4.

Abstract

The accumulation of amyloid-beta peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-beta peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / genetics*
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Aspartic Acid Endopeptidases
  • Endopeptidases / genetics*
  • Humans
  • LDL-Receptor Related Proteins
  • Membrane Proteins / genetics
  • Membrane Transport Proteins / genetics*
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Presenilin-1
  • Receptors, LDL / genetics*

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • LDL-Receptor Related Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • Receptors, LDL
  • SORL1 protein, human
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human
  • Bace1 protein, mouse