Abstract
A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / pathology
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Fluorescent Antibody Technique
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Gene Expression Regulation, Neoplastic
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Muscle Proteins / genetics
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Muscle Proteins / metabolism*
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Muscles / pathology*
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MyoD Protein
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Sarcoma / genetics
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Sarcoma / metabolism*
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Sarcoma / pathology
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Soft Tissue Neoplasms / genetics
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Soft Tissue Neoplasms / metabolism*
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Soft Tissue Neoplasms / pathology
Substances
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Muscle Proteins
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MyoD Protein