Preliminary study of the relationship between DAZ gene copy deletions and spermatogenic impairment in Chinese men

Fertil Steril. 2006 Apr;85(4):1061-3. doi: 10.1016/j.fertnstert.2005.09.025.

Abstract

Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men. The deletion patterns correlate with spermatogenic impairment in a Chinese population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics*
  • Deleted in Azoospermia 1 Protein
  • Gene Deletion*
  • Gene Dosage*
  • Humans
  • Infertility, Male / genetics*
  • Male
  • RNA-Binding Proteins / genetics*
  • Spermatogenesis / genetics*

Substances

  • DAZ1 protein, human
  • Deleted in Azoospermia 1 Protein
  • RNA-Binding Proteins