[Genetic polymorphism of glutathione-S-transferase M1 and T1 in children with acute lymphoblastic leukemia]

Klin Lab Diagn. 2006 Feb:(2):23-4, 33-4.
[Article in Russian]

Abstract

Children with acute lymphoblastic leukemia (ALL) and deletions of glutathione-S-transferase M1 (GSTMI) and glutathione-S-transferase T1 (GSTT1) have better event-free survival and lower rates of relapses than those with GSTM1 and/or GSTT1. It is concluded that deletions of GSTM1 and/or GSTT1, double-null genotype are closely associated with the good prognosis of childhood ALL treated according to the ALL-BFM 90 and ALL-MB 91 protocols.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Female
  • Gene Deletion*
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Predictive Value of Tests
  • Survival Rate

Substances

  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1