Abstract
Children with acute lymphoblastic leukemia (ALL) and deletions of glutathione-S-transferase M1 (GSTMI) and glutathione-S-transferase T1 (GSTT1) have better event-free survival and lower rates of relapses than those with GSTM1 and/or GSTT1. It is concluded that deletions of GSTM1 and/or GSTT1, double-null genotype are closely associated with the good prognosis of childhood ALL treated according to the ALL-BFM 90 and ALL-MB 91 protocols.
MeSH terms
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Adolescent
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Child
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Child, Preschool
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Disease-Free Survival
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Female
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Gene Deletion*
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Glutathione Transferase / genetics*
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Humans
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Male
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Polymorphism, Genetic*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
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Predictive Value of Tests
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Survival Rate
Substances
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glutathione S-transferase T1
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Glutathione Transferase
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glutathione S-transferase M1