Abstract
Human leukocyte antigen G (HLA-G) molecules exhibit immunomodulatory properties corresponding to nonclassic class I genes of the major histocompatibility complex. They are either membrane-bound or solubly expressed during certain tumoral malignancies. Soluble human leukocyte antigen G (sHLA-G) molecules seem more frequently expressed than membrane-bound isoforms during hematologic malignancies, such as lymphoproliferative disorders. Assay of these molecules by enzyme-linked immunosorbent assay in patients suffering from another hematologic disorder (acute leukemia) highlights increased sHLA-G secretion. This increased secretion seems more marked in acute leukemia subtypes affecting monocytic and lymphoid lineages such as FABM4 and FABM5, as well as both B and T acute lymphoblastic leukemia (ALL). Moreover, this study uses in vitro cytokine stimulations and reveals the respective potential roles of granulocyte-macrophage colony-stimulating factor and interferon-gamma in increasing this secretion in FABM4 and ALL. Correlations between sHLA-G plasma level and clinical biologic features suggest a link between elevated sHLA-G level and 1) the absence of anterior myelodysplasia and 2) high-level leukocytosis. All these findings suggest that sHLA-G molecules could be a factor in tumoral escape from immune survey during acute leukemia.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Antigens, Neoplasm / biosynthesis
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Antigens, Neoplasm / blood*
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Antigens, Neoplasm / genetics
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Biomarkers, Tumor / blood
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Burkitt Lymphoma / blood
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / metabolism
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Burkitt Lymphoma / pathology
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Cell Line, Tumor / chemistry
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Cell Line, Tumor / drug effects
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Cell Line, Tumor / metabolism
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Cytokines / blood
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Cytokines / pharmacology
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Enzyme-Linked Immunosorbent Assay
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Gene Expression Regulation, Leukemic / drug effects
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HLA Antigens / biosynthesis
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HLA Antigens / blood*
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HLA Antigens / genetics
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HLA-G Antigens
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Histocompatibility Antigens Class I / biosynthesis
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Histocompatibility Antigens Class I / blood*
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Histocompatibility Antigens Class I / genetics
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Humans
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Leukemia / blood*
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Leukemia / classification
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Leukemia / genetics
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Leukemia / metabolism
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Leukemia, Myeloid / blood
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Leukemia, Myeloid / classification
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Leukemia, Myeloid / genetics
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Leukemia, Myeloid / metabolism
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Leukemia, Myeloid / pathology
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Leukemia-Lymphoma, Adult T-Cell / blood
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / metabolism
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Retrospective Studies
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Solubility
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Tumor Escape
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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Cytokines
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I