Abstract
Recently, a new class of regulatory molecules has emerged; these molecules, termed SOCS proteins, function as suppressors of cytokine signaling. SOCS proteins negatively regulate the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling cascade. Interestingly, it appears that other proteins, such as caveolin-1, can also function as suppressors of cytokine signaling by inhibiting the kinase activity of JAK family members. This might result from the ability of caveolin-1 to function as a broad-spectrum kinase inhibitor through the caveolin-scaffolding domain.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Caveolin 1 / deficiency
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Caveolin 1 / genetics
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Caveolin 1 / physiology*
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Diabetes Mellitus
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Genes, Tumor Suppressor
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Hormones / metabolism*
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Humans
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Hypersensitivity
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Inflammation
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Janus Kinase 1
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Janus Kinase 2
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Janus Kinase 3
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Mice
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Mice, Knockout
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Neoplasms
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins / antagonists & inhibitors
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Proto-Oncogene Proteins / metabolism
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STAT Transcription Factors / antagonists & inhibitors
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Signal Transduction / physiology*
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Suppressor of Cytokine Signaling Proteins / deficiency
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Suppressor of Cytokine Signaling Proteins / genetics
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Suppressor of Cytokine Signaling Proteins / physiology*
Substances
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Caveolin 1
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Hormones
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Proto-Oncogene Proteins
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STAT Transcription Factors
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Suppressor of Cytokine Signaling Proteins
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Protein-Tyrosine Kinases
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JAK1 protein, human
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JAK2 protein, human
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JAK3 protein, human
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Jak1 protein, mouse
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Jak2 protein, mouse
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Jak3 protein, mouse
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Janus Kinase 1
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Janus Kinase 2
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Janus Kinase 3