Genes of type 2 diabetes in beta cells

Endocrinol Metab Clin North Am. 2006 Jun;35(2):357-69, x. doi: 10.1016/j.ecl.2006.02.008.

Abstract

Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.

Publication types

  • Review

MeSH terms

  • Autoantigens / genetics
  • Autoantigens / physiology
  • Calpain / genetics*
  • Calpain / physiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Genetic Predisposition to Disease
  • Humans
  • Insulin-Secreting Cells / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Polymorphism, Genetic
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / physiology
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8

Substances

  • Autoantigens
  • Membrane Proteins
  • PTPRN protein, human
  • Protein Tyrosine Phosphatases
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8
  • Calpain
  • calpain 10