Abstract
Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Basal Ganglia / injuries
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Basal Ganglia / metabolism
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Basal Ganglia / pathology
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Caudate Nucleus / injuries
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Caudate Nucleus / metabolism
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Caudate Nucleus / pathology
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Cerebral Cortex / injuries*
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Cerebral Cortex / metabolism*
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Cerebral Cortex / pathology
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Chemokine CCL2 / blood*
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Female
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HIV Infections / blood*
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HIV Infections / complications*
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HIV Infections / pathology
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Hematocrit
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Humans
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Male
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Middle Aged
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Putamen / injuries
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Putamen / metabolism
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Putamen / pathology
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Chemokine CCL2
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Tumor Necrosis Factor-alpha