Abstract
Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.
MeSH terms
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Animals
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Cell Line
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Cell Transformation, Viral*
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Chickens
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Fibroblasts / metabolism
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Fibroblasts / pathology
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Fibroblasts / virology
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Gene Expression Regulation, Leukemic / physiology
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Gene Expression Regulation, Viral / physiology
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Genome
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Humans
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Integrin alpha Chains / biosynthesis
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Integrin beta Chains / biosynthesis
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Lymphoma, T-Cell / enzymology*
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Lymphoma, T-Cell / genetics
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Lymphoma, T-Cell / pathology
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Lymphoma, T-Cell / virology
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Mardivirus / enzymology*
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Mardivirus / genetics
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Marek Disease / enzymology
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Marek Disease / genetics
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Marek Disease / pathology
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Marek Disease / virology
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Mice
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Mutation
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Sequence Homology, Amino Acid
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Telomerase / genetics
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Telomerase / metabolism*
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Viral Proteins / genetics
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Viral Proteins / metabolism*
Substances
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Integrin alpha Chains
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Integrin beta Chains
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Viral Proteins
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Telomerase