Abstract
Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.
MeSH terms
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Angiogenesis Inducing Agents
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Apoptosis / physiology
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Cell Differentiation / physiology
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Cell Movement / physiology
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Eye Proteins / physiology*
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Frizzled Receptors / physiology*
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Humans
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Neovascularization, Physiologic / physiology
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Nerve Tissue Proteins / physiology*
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Retinal Vessels / physiology
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Signal Transduction / physiology*
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Vascular Diseases / physiopathology
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Wnt Proteins / physiology*
Substances
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Angiogenesis Inducing Agents
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Eye Proteins
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Frizzled Receptors
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NDP protein, human
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Nerve Tissue Proteins
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Wnt Proteins