A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases

M Timón; A Arnaiz-Villena; P Pérez-Aciego; P Morales; D Benmamar; J R Regueiro

doi:10.1007/BF00201834

A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases

Hum Genet. 1991 Feb;86(4):363-4. doi: 10.1007/BF00201834.

Authors

M Timón¹, A Arnaiz-Villena, P Pérez-Aciego, P Morales, D Benmamar, J R Regueiro

Affiliation

¹ Hospital 12 De Octubre, Madrid, Spain.

PMID: 1671848
DOI: 10.1007/BF00201834

Abstract

A diallelic restriction fragment length polymorphism of the CD3-epsilon (epsilon) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-epsilon chain cDNA probe. This combination shows two alleles of 9.1 kb and 8.4 kb with a frequency of 0.66 and 0.34, respectively, in the Spanish population. None of these alleles is associated with susceptibility to juvenile rheumatoid arthritis (JRA) or insulin-dependent diabetes mellitus (IDDM).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Antigens, CD / genetics*
Antigens, Differentiation, T-Lymphocyte / genetics*
Arthritis, Juvenile / genetics
Arthritis, Juvenile / immunology
Autoimmune Diseases / genetics*
Autoimmune Diseases / immunology
CD3 Complex
Diabetes Mellitus, Type 1 / genetics
Diabetes Mellitus, Type 1 / immunology
Female
Gene Frequency
Genotype
Humans
Macromolecular Substances
Male
Pedigree
Polymorphism, Restriction Fragment Length*
Receptors, Antigen, T-Cell / genetics*

Substances

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
Macromolecular Substances
Receptors, Antigen, T-Cell