Abstract
The action and interaction of ACTH and prolactin in the development of fatty liver were investigated in intact rats treated with exogenous hormones. Administration of ACTH or of combinations of ACTH and GH to intact female rats was found to elicit significantly greater increase in liver total lipids content and concentration than administration of combinations of ACTH, or ACTH and GH, with prolactin. In addition, the results support the data reported by Bates et al. (6) that simultaneous application of GH, prolactin and ACTH reduces the effct of ACTH, upon adrenal gland weight.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenal Glands / metabolism
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Adrenocorticotropic Hormone / administration & dosage
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Adrenocorticotropic Hormone / antagonists & inhibitors*
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Adrenocorticotropic Hormone / pharmacology
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Animals
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Fatty Liver / chemically induced*
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Female
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Growth Hormone / administration & dosage
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Growth Hormone / antagonists & inhibitors
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Growth Hormone / pharmacology
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Liver / drug effects
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Organ Size
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Phospholipids / metabolism
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Prolactin / administration & dosage
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Prolactin / pharmacology*
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Rats
Substances
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Phospholipids
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Adrenocorticotropic Hormone
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Prolactin
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Growth Hormone