Abstract
Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Chromosomes, Human, Pair 10
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Chromosomes, Human, Pair 14
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Cloning, Molecular
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Gene Expression Regulation, Neoplastic*
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Genes, Homeobox*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics*
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Mice
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Molecular Sequence Data
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Receptors, Antigen, T-Cell / genetics
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Translocation, Genetic*
Substances
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Receptors, Antigen, T-Cell
Associated data
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GENBANK/M63875
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GENBANK/M74516
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GENBANK/M74517
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GENBANK/M76239
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GENBANK/M76240
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GENBANK/M76241
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GENBANK/M76242
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GENBANK/M76243
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GENBANK/M76244
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GENBANK/S38742