Abstract
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
Publication types
-
Clinical Trial
-
Multicenter Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Child
-
Cohort Studies
-
DNA Mutational Analysis
-
Female
-
Genetic Predisposition to Disease / genetics
-
HLA-DR Antigens / genetics*
-
HLA-DR Antigens / immunology*
-
HLA-DR Serological Subtypes
-
Humans
-
Male
-
Middle Aged
-
Mutation
-
Myasthenia Gravis / genetics*
-
Myasthenia Gravis / immunology*
-
Netherlands / epidemiology
-
Prevalence
-
Receptor Protein-Tyrosine Kinases / immunology*
-
Receptors, Cholinergic / immunology*
-
Risk Assessment / methods*
-
Risk Factors
-
Statistics as Topic
Substances
-
HLA-DR Antigens
-
HLA-DR Serological Subtypes
-
HLA-DR14
-
Receptors, Cholinergic
-
MUSK protein, human
-
Receptor Protein-Tyrosine Kinases