Abstract
We describe a case of coexisting BCR-ABL negative myeloproliferative disorder and precursor T-cell lymphoblastic lymphoma associated with t(8;13) involving FGFR1 at 8p11 in a 14-year-old boy who presented with generalized lymphadenopathy and an abdominal mass. JAK2 mutation and FIP1L1-PDGFRalpha were not detected. RT-PCR revealed the ZNF198-FGFR1 fusion transcript in both the bone marrow (BM) and lymph node (LN) of the patient at diagnosis. Of interest, reciprocal FGFR1-ZNF198 fusion transcript was demonstrated in the BM but not LN. Also differential clonal TcRgamma gene rearrangements in the BM and LN samples were observed. These findings provide novel insights into the genetic pathogenesis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Bone Marrow / pathology
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Cell Transformation, Neoplastic / genetics
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China / epidemiology
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Chromosomes, Human, Pair 13 / genetics*
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Chromosomes, Human, Pair 8 / genetics*
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Clone Cells
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Disease Progression
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Genes, T-Cell Receptor gamma / genetics
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Hematopoietic Stem Cells / pathology
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Humans
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Male
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Myeloproliferative Disorders / diagnosis
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Myeloproliferative Disorders / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Receptor, Fibroblast Growth Factor, Type 1 / genetics
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Remission Induction
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Syndrome
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Translocation, Genetic / genetics
Substances
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Receptor, Fibroblast Growth Factor, Type 1