Abstract
Yanagihori et al. found an HLA-independent higher frequency of IL-12B promoter polymorphism in Adamantiades-Behçet's disease (ABD) patients than in controls. Stimulation with streptococcal antigens specifically increased expression of patients' peripheral blood mononuclear cells IL-12 p40/p70. The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent.
MeSH terms
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Antigens, Bacterial / immunology
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Behcet Syndrome / genetics
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Behcet Syndrome / immunology*
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Behcet Syndrome / physiopathology*
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Biomarkers, Tumor / physiology
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DNA-Binding Proteins / physiology
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Gene Expression Regulation / immunology
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Genetic Predisposition to Disease / genetics
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HLA Antigens / genetics
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HLA Antigens / immunology*
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Heterozygote
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Humans
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Interleukin-12 / genetics
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Interleukin-12 / physiology*
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Mycoplasma fermentans / immunology
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Phosphopyruvate Hydratase / physiology
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Polymorphism, Genetic
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Promoter Regions, Genetic / genetics
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Streptococcal Infections / immunology
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Streptococcus sanguis / immunology
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Th1 Cells / immunology*
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Th1 Cells / physiology
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Tumor Suppressor Proteins / physiology
Substances
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Antigens, Bacterial
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Biomarkers, Tumor
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DNA-Binding Proteins
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HLA Antigens
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Tumor Suppressor Proteins
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Interleukin-12
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ENO1 protein, human
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Phosphopyruvate Hydratase