HLA-independent antibacterial host response toward Th1 immunity mediated by IL-12: a new concept for the pathogenesis of Adamantiades-Behçet's disease

J Invest Dermatol. 2006 Jul;126(7):1444-7. doi: 10.1038/sj.jid.5700281.

Abstract

Yanagihori et al. found an HLA-independent higher frequency of IL-12B promoter polymorphism in Adamantiades-Behçet's disease (ABD) patients than in controls. Stimulation with streptococcal antigens specifically increased expression of patients' peripheral blood mononuclear cells IL-12 p40/p70. The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent.

Publication types

  • Comment

MeSH terms

  • Antigens, Bacterial / immunology
  • Behcet Syndrome / genetics
  • Behcet Syndrome / immunology*
  • Behcet Syndrome / physiopathology*
  • Biomarkers, Tumor / physiology
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation / immunology
  • Genetic Predisposition to Disease / genetics
  • HLA Antigens / genetics
  • HLA Antigens / immunology*
  • Heterozygote
  • Humans
  • Interleukin-12 / genetics
  • Interleukin-12 / physiology*
  • Mycoplasma fermentans / immunology
  • Phosphopyruvate Hydratase / physiology
  • Polymorphism, Genetic
  • Promoter Regions, Genetic / genetics
  • Streptococcal Infections / immunology
  • Streptococcus sanguis / immunology
  • Th1 Cells / immunology*
  • Th1 Cells / physiology
  • Tumor Suppressor Proteins / physiology

Substances

  • Antigens, Bacterial
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • HLA Antigens
  • Tumor Suppressor Proteins
  • Interleukin-12
  • ENO1 protein, human
  • Phosphopyruvate Hydratase